Electroencephalogram

The invention: A system of electrodes that measures brain wave
patterns in humans, making possible a new era of neurophysiology.
The people behind the invention:
Hans Berger (1873-1941), a German psychiatrist and research
scientist
Richard Caton (1842-1926), an English physiologist and surgeon
The Electrical Activity of the Brain
Hans Berger’s search for the human electroencephalograph (English
physiologist Richard Caton had described the electroencephalogram,
or “brain wave,” in rabbits and monkeys in 1875) was motivated
by his desire to find a physiological method that might be
applied successfully to the study of the long-standing problem of
the relationship between the mind and the brain. His scientific career,
therefore, was directed toward revealing the psychophysical
relationship in terms of principles that would be rooted firmly in the
natural sciences and would not have to rely upon vague philosophical
or mystical ideas.
During his early career, Berger attempted to study psychophysical
relationships by making plethysmographic measurements of
changes in the brain circulation of patients with skull defects. In
plethysmography, an instrument is used to indicate and record by
tracings the variations in size of an organ or part of the body. Later,
Berger investigated temperature changes occurring in the human
brain during mental activity and the action of psychoactive drugs.
He became disillusioned, however, by the lack of psychophysical
understanding generated by these investigations.
Next, Berger turned to the study of the electrical activity of the
brain, and in the 1920’s he set out to search for the human electroencephalogram.
He believed that the electroencephalogram would finally
provide him with a physiological method capable of furnishing
insight into mental functions and their disturbances.Berger made his first unsuccessful attempt at recording the electrical
activity of the brain in 1920, using the scalp of a bald medical
student. He then attempted to stimulate the cortex of patients with
skull defects by using a set of electrodes to apply an electrical current
to the skin covering the defect. The main purpose of these
stimulation experiments was to elicit subjective sensations. Berger
hoped that eliciting these sensations might give him some clue
about the nature of the relationship between the physiochemical
events produced by the electrical stimulus and the mental processes
revealed by the patients’ subjective experience. The availability
of many patients with skull defects—in whom the pulsating
surface of the brain was separated from the stimulating electrodes
by only a few millimeters of tissue—reactivated Berger’s interest
in recording the brain’s electrical activity.Small, Tremulous Movements
Berger used several different instruments in trying to detect
brain waves, but all of them used a similar method of recording.
Electrical oscillations deflected a mirror upon which a light beam
was projected. The deflections of the light beam were proportional
to the magnitude of the electrical signals. The movement of the spot
of the light beam was recorded on photographic paper moving at a
speed no greater than 3 centimeters per second.
In July, 1924, Berger observed small, tremulous movements of
the instrument while recording from the skin overlying a bone defect
in a seventeen-year-old patient. In his first paper on the electroencephalogram,
Berger described this case briefly as his first successful
recording of an electroencephalogram. At the time of these
early studies, Berger already had used the term “electroencephalogram”
in his diary. Yet for several years he had doubts about the origin
of the electrical signals he recorded. As late as 1928, he almost
abandoned his electrical recording studies.
The publication of Berger’s first paper on the human encephalogram
in 1929 had little impact on the scientific world. It was either
ignored or regarded with open disbelief. At this time, even
when Berger himself was not completely free of doubts about the
validity of his findings, he managed to continue his work. He published
additional contributions to the study of the electroencephalogram
in a series of fourteen papers. As his research progressed,
Berger became increasingly confident and convinced of the significance
of his discovery.
Impact
The long-range impact of Berger’s work is incontestable. When
Berger published his last paper on the human encephalogram in
1938, the new approach to the study of brain function that he inaugurated
in 1929 had gathered momentum in many centers, both in
Europe and in the United States. As a result of his pioneering work,
a new diagnostic method had been introduced into medicine. Physiology
had acquired a new investigative tool. Clinical neurophysiology
had been liberated from its dependence upon the functional anatomical approach, and electrophysiological exploration of complex
functions of the central nervous system had begun in earnest.
Berger’s work had finally received its well-deserved recognition.
Many of those who undertook the study of the electroencephalogram
were able to bring a far greater technical knowledge of
neurophysiology to bear upon the problems of the electrical activity
of the brain. Yet the community of neurological scientists has not
ceased to look with respect to the founder of electroencephalography,
who, despite overwhelming odds and isolation, opened a new
area of neurophysiology.