Laser vaporization

The invention: Technique using laser light beams to vaporize the
plaque that clogs arteries.
The people behind the invention:
Albert Einstein (1879-1955), a theoretical American physicist
Theodore Harold Maiman (1927- ), inventor of the laser
Light, Lasers, and Coronary Arteries
Visible light, a type of electromagnetic radiation, is actually a
form of energy. The fact that the light beams produced by a light
bulb can warm an object demonstrates that this is the case. Light
beams are radiated in all directions by a light bulb. In contrast, the
device called the “laser” produces light that travels in the form of a
“coherent” unidirectional beam. Coherent light beams can be focused
on very small areas, generating sufficient heat to melt steel.
The term “laser” was invented in 1957 by R. Gordon Gould of
Columbia University. It stands for light amplification by stimulated
emission of radiation, the means by which laser light beams are
made. Many different materials—including solid ruby gemstones,
liquid dye solutions, and mixtures of gases—can produce such
beams in a process called “lasing.” The different types of lasers yield
light beams of different colors that have many uses in science, industry,
and medicine. For example, ruby lasers, which were developed
in 1960, are widely used in eye surgery. In 1983, a group of
physicians in Toulouse, France, used a laser for cardiovascular treatment.
They used the laser to vaporize the “atheroma” material that
clogs the arteries in the condition called “atherosclerosis.” The technique
that they used is known as “laser vaporization surgery.”
Laser Operation, Welding, and Surgery
Lasers are electronic devices that emit intense beams of light
when a process called “stimulated emission” occurs. The principles
of laser operation, including stimulated emission, were established
by Albert Einstein and other scientists in the first third of the twentieth century. In 1960, Theodore H. Maiman of the Hughes Research
Center in Malibu, California, built the first laser, using a ruby crystal
to produce a laser beam composed of red light.
All lasers are made up of three main components. The first of
these, the laser’s “active medium,” is a solid (like Maiman’s ruby
crystal), a liquid, or a gas that can be made to lase. The second component
is a flash lamp or some other light energy source that puts
light into the active medium. The third component is a pair of mirrors
that are situated on both sides of the active medium and are designed
in such a way that one mirror transmits part of the energy
that strikes it, yielding the light beam that leaves the laser.
Lasers can produce energy because light is one of many forms of
energy that are called, collectively, electromagnetic radiation (among
the other forms of electromagnetic radiation are X rays and radio
waves). These forms of electromagnetic radiation have different wavelengths;
the smaller the wavelength, the higher the energy level. The
energy level is measured in units called “quanta.” The emission of
light quanta from atoms that are said to be in the “excited state” produces
energy, and the absorption of quanta by unexcited atoms—
atoms said to be in the “ground state”—excites those atoms.
The familiar light bulb spontaneously and haphazardly emits
light of many wavelengths from excited atoms. This emission occurs
in all directions and at widely varying times. In contrast, the
light reflection between the mirrors at the ends of a laser causes all
of the many excited atoms present in the active medium simultaneously
to emit light waves of the same wavelength. This process is
called “stimulated emission.”
Stimulated emission ultimately causes a laser to yield a beam of
coherent light, which means that the wavelength, emission time,
and direction of all the waves in the laser beam are the same. The
use of focusing devices makes it possible to convert an emitted laser
beam into a point source that can be as small as a few thousandths of
an inch in diameter. Such focused beams are very hot, and they can
be used for such diverse functions as cutting or welding metal objects
and performing delicate surgery. The nature of the active medium
used in a laser determines the wavelength of its emitted light
beam; this in turn dictates both the energy of the emitted quanta and
the appropriate uses for the laser.Maiman’s ruby laser, for example, has been used since the 1960’s
in eye surgery to reattach detached retinas. This is done by focusing
the laser on the tiny retinal tear that causes a retina to become detached.
The very hot, high-intensity light beam then “welds” the
retina back into place, bloodlessly, by burning it to produce scar tissue.
The burning process has no effect on nearby tissues. Other
types of lasers have been used in surgeries on the digestive tract and
the uterus since the 1970’s.
In 1983, a group of physicians began using lasers to treat cardiovascular
disease. The original work, which was carried out by a
number of physicians in Toulouse, France, involved the vaporization
of atheroma deposits (atherosclerotic plaque) in a human artery. This very exciting event added a new method to medical science’s
arsenal of life-saving techniques.
Consequences
Since their discovery, lasers have been used for many purposes
in science and industry. Such uses include the study of the laws of
chemistry and physics, photography, communications, and surveying.
Lasers have been utilized in surgery since the mid-1960’s, and
their use has had a tremendous impact on medicine. The first type
of laser surgery to be conducted was the repair of detached retinas
via ruby lasers. This technique has become the method of choice for
such eye surgery because it takes only minutes to perform rather
than the hours required for conventional surgical methods. It is also
beneficial because the lasing of the surgical site cauterizes that site,
preventing bleeding.
In the late 1970’s, the use of other lasers for abdominal cancer
surgery and uterine surgery began and flourished. In these
forms of surgery, more powerful lasers are used. In the 1980’s,
laser vaporization surgery (LVS) began to be used to clear atherosclerotic
plaque (atheromas) from clogged arteries. This methodology
gives cardiologists a useful new tool. Before LVS was
available, surgeons dislodged atheromas by means of “transluminal
angioplasty,” which involved pushing small, fluoroscopeguided
inflatable balloons through clogged arteries.

Laser eye surgery

The invention: The first significant clinical ophthalmic application
of any laser system was the treatment of retinal tears with a
pulsed ruby laser.
The people behind the invention:
Charles J. Campbell (1926- ), an ophthalmologist
H. Christian Zweng (1925- ), an ophthalmologist
Milton M. Zaret (1927- ), an ophthalmologist
Theodore Harold Maiman (1927- ), the physicist who
developed the first laser
Monkeys and Rabbits
The term “laser” is an acronym for light amplification by the
stimulated emission of radiation. The development of the laser for
ophthalmic (eye surgery) surgery arose from the initial concentration
of conventional light by magnifying lenses.
Within a laser, atoms are highly energized. When one of these atoms
loses its energy in the form of light, it stimulates other atoms to
emit light of the same frequency and in the same direction. A cascade
of these identical light waves is soon produced, which then oscillate
back and forth between the mirrors in the laser cavity. One
mirror is only partially reflective, allowing some of the laser light to
pass through. This light can be concentrated further into a small
burst of high intensity.
On July 7, 1960, Theodore Harold Maiman made public his discovery
of the first laser—a ruby laser. Shortly thereafter, ophthalmologists
began using ruby lasers for medical purposes.
The first significant medical uses of the ruby laser occurred in
1961, with experiments on animals conducted by Charles J. Campbell
in New York, H. Christian Zweng, and Milton M. Zaret. Zaret and his
colleagues produced photocoagulation (a thickening or drawing together
of substances by use of light) of the eyes of rabbits by flashes
froma ruby laser. Sufficient energy was delivered to cause immediate
thermal injury to the retina and iris of the rabbit. The beam also was directed to the interior of the rabbit eye, resulting in retinal coagulations.
The team examined the retinal lesions and pointed out both
the possible advantages of laser as a tool for therapeutic photocoagulation
and the potential applications in medical research.
In 1962, Zweng, along with several of his associates, began experimenting
with laser photocoagulation on the eyes of monkeys
and rabbits in order to establish parameters for the use of lasers on
the human eye.
Reflected by Blood
The vitreous humor, a transparent jelly that usually fills the vitreous
cavity of the eyes of younger individuals, commonly shrinks with age,
with myopia, or with certain pathologic conditions. As these conditions
occur, the vitreous humor begins to separate from the adjacent
retina. In some patients, the separating vitreous humor produces a
traction (pulling), causing a retinal tear to form. Through this opening in
the retina, liquefied vitreous humor can pass to a site underneath the
retina, producing retinal detachment and loss of vision.
Alaser can be used to cause photocoagulation of a retinal tear. As a
result, an adhesive scar forms between the retina surrounding the
tear and the underlying layers so that, despite traction, the retina
does not detach. If more than a small area of retina has detached, the
laser often is ineffective and major retinal detachment surgery must
be performed. Thus, in the experiments of Campbell and Zweng, the
ruby laser was used to prevent, rather than treat, retinal detachment.
In subsequent experiments with humans, all patients were treated
with the experimental laser photocoagulator without anesthesia.
Although usually no attempt was made to seal holes or tears, the
diseased portions of the retina were walled off satisfactorily so that
no detachments occurred. One problem that arose involved microaneurysms.
A“microaneurysm” is a tiny aneurysm, or blood-filled
bubble extending from the wall of a blood vessel. When attempts to
obliterate microaneurysms were unsuccessful, the researchers postulated
that the color of the ruby pulse so resembled the red of blood
that the light was reflected rather than absorbed. They believed that
another lasing material emitting light in another part of the spectrum
might have performed more successfully.Previously, xenon-arc lamp photocoagulators had been used to
treat retinal tears. The long exposure time required of these systems,
combined with their broad spectral range emission (versus
the single wavelength output of a laser), however, made the retinal
spot on which the xenon-arc could be focused too large for many
applications. Focused laser spots on the retina could be as small as
50 microns.
Consequences
The first laser in ophthalmic use by Campbell, Zweng, and Zaret,
among others, was a solid laser—Maiman’s ruby laser. While the results
they achieved with this laser were more impressive than with
the previously used xenon-arc, in the decades following these experiments,
argon gas replaced ruby as the most frequently used material
in treating retinal tears.
Argon laser energy is delivered to the area around the retinal tear
through a slit lamp or by using an intraocular probe introduced directly
into the eye. The argon wavelength is transmitted through the
clear structures of the eye, such as the cornea, lens, and vitreous.
This beam is composed of blue-green light that can be effectively
aimed at the desired portion of the eye. Nevertheless, the beam can
be absorbed by cataracts and by vitreous or retinal blood, decreasing
its effectiveness.
Moreover, while the ruby laser was found to be highly effective
in producing an adhesive scar, it was not useful in the treatment of
vascular diseases of the eye. Aseries of laser sources, each with different
characteristics, was considered, investigated, and used clinically
for various durations during the period that followed Campbell
and Zweng’s experiments.
Other laser types that are being adapted for use in ophthalmology
are carbon dioxide lasers for scleral surgery (surgery on the
tough, white, fibrous membrane covering the entire eyeball except
the area covered by the cornea) and eye wall resection, dye lasers to
kill or slow the growth of tumors, eximer lasers for their ability to
break down corneal tissue without heating, and pulsed erbium lasers
used to cut intraocular membranes.

Laser-diode recording process

The invention: Video and audio playback system that uses a lowpower
laser to decode information digitally stored on reflective
disks.
The organization behind the invention:
The Philips Corporation, a Dutch electronics firm
The Development of Digital Systems
Since the advent of the computer age, it has been the goal of
many equipment manufacturers to provide reliable digital systems
for the storage and retrieval of video and audio programs. A need
for such devices was perceived for several reasons. Existing storage
media (movie film and 12-inch, vinyl, long-playing records) were
relatively large and cumbersome to manipulate and were prone to
degradation, breakage, and unwanted noise. Thus, during the late
1960’s, two different methods for storing video programs on disc
were invented. A mechanical system was demonstrated by the
Telefunken Company, while the Radio Corporation of America
(RCA) introduced an electrostatic device (a device that used static
electricity). The first commercially successful system, however, was
developed during the mid-1970’s by the Philips Corporation.
Philips devoted considerable resources to creating a digital video
system, read by light beams, which could reproduce an entire feature-
length film from one 12-inch videodisc. An integral part of this
innovation was the fabrication of a device small enough and fast
enough to read the vast amounts of greatly compacted data stored
on the 12-inch disc without introducing unwanted noise. Although
Philips was aware of the other formats, the company opted to use an
optical scanner with a small “semiconductor laser diode” to retrieve
the digital information. The laser diode is only a fraction of a millimeter
in size, operates quite efficiently with high amplitude and relatively
low power (0.1 watt), and can be used continuously. Because
this configuration operates at a high frequency, its informationcarrying
capacity is quite large.Although the digital videodisc system (called “laservision”) works
well, the low level of noise and the clear images offered by this system
were masked by the low quality of the conventional television
monitors on which they were viewed. Furthermore, the high price
of the playback systems and the discs made them noncompetitive
with the videocassette recorders (VCRs) that were then capturing
the market for home systems. VCRs had the additional advantage
that programs could be recorded or copied easily. The Philips Corporation
turned its attention to utilizing this technology in an area
where low noise levels and high quality would be more readily apparent—
audio disc systems. By 1979, they had perfected the basic
compact disc (CD) system, which soon revolutionized the world of
stereophonic home systems.
Reading Digital Discs with Laser Light
Digital signals (signals composed of numbers) are stored on
discs as “pits” impressed into the plastic disc and then coated with a
thin reflective layer of aluminum. A laser beam, manipulated by
delicate, fast-moving mirrors, tracks and reads the digital information
as changes in light intensity. These data are then converted to a
varying electrical signal that contains the video or audio information.
The data are then recovered by means of a sophisticated
pickup that consists of the semiconductor laser diode, a polarizing
beam splitter, an objective lens, a collective lens system, and a
photodiode receiver. The beam from the laser diode is focused by a
collimator lens (a lens that collects and focuses light) and then
passes through the polarizing beam splitter (PBS). This device acts
like a one-way mirror mounted at 45 degrees to the light path. Light
from the laser passes through the PBS as if it were a window, but the
light emerges in a polarized state (which means that the vibration of
the light takes place in only one plane). For the beam reflected from
the CD surface, however, the PBS acts like a mirror, since the reflected
beam has an opposite polarization. The light is thus deflected
toward the photodiode detector. The objective lens is needed
to focus the light onto the disc surface. On the outer surface of the
transparent disc, the main spot of light has a diameter of 0.8 millimeter,
which narrows to only 0.0017 millimeter at the reflective surface. At the surface, the spot is about three times the size of the microscopic
pits (0.0005 millimeter).
The data encoded on the disc determine the relative intensity of
the reflected light, on the basis of the presence or absence of pits.
When the reflected laser beam enters the photodiode, a modulated
light beam is changed into a digital signal that becomes an analog
(continuous) audio signal after several stages of signal processing
and error correction.
Consequences
The development of the semiconductor laser diode and associated
circuitry for reading stored information has made CD audio
systems practical and affordable. These systems can offer the quality
of a live musical performance with a clarity that is undisturbed
by noise and distortion. Digital systems also offer several other significant
advantages over analog devices. The dynamic range (the
difference between the softest and the loudest signals that can be
stored and reproduced) is considerably greater in digital systems. In
addition, digital systems can be copied precisely; the signal is not
degraded by copying, as is the case with analog systems. Finally,
error-correcting codes can be used to detect and correct errors in
transmitted or reproduced digital signals, allowing greater precision
and a higher-quality output sound.
Besides laser video systems, there are many other applications
for laser-read CDs. Compact disc read-only memory (CD-ROM) is
used to store computer text. One standard CD can store 500 megabytes
of information, which is about twenty times the storage of a
hard-disk drive on a typical home computer. Compact disc systems
can also be integrated with conventional televisions (called CD-V)
to present twenty minutes of sound and five minutes of sound with
picture. Finally, CD systems connected with a computer (CD-I) mix
audio, video, and computer programming. These devices allow the
user to stop at any point in the program, request more information,
and receive that information as sound with graphics, film clips, or
as text on the screen.

Laser

The invention: Taking its name from the acronym for light amplification
by the stimulated emission of radiation, a laser is a
beam of electromagnetic radiation that is monochromatic, highly
directional, and coherent. Lasers have found multiple applications
in electronics, medicine, and other fields.
The people behind the invention:
Theodore Harold Maiman (1927- ), an American physicist
Charles Hard Townes (1915- ), an American physicist who
was a cowinner of the 1964 Nobel Prize in Physics
Arthur L. Schawlow (1921-1999), an American physicist,
cowinner of the 1981 Nobel Prize in Physics
Mary Spaeth (1938- ), the American inventor of the tunable
laser
Coherent Light
Laser beams differ from other forms of electromagnetic radiation
in being consisting of a single wavelength, being highly directional,
and having waves whose crests and troughs are aligned. A laser
beam launched from Earth has produced a spot a few kilometers
wide on the Moon, nearly 400,000 kilometers away. Ordinary light
would have spread much more and produced a spot several times
wider than the Moon. Laser light can also be concentrated so as to
yield an enormous intensity of energy, more than that of the surface
of the Sun, an impossibility with ordinary light.
In order to appreciate the difference between laser light and ordinary
light, one must examine how light of any kind is produced. An
ordinary light bulb contains atoms of gas. For the bulb to light up,
these atoms must be excited to a state of energy higher then their
normal, or ground, state. This is accomplished by sending a current
of electricity through the bulb; the current jolts the atoms into the
higher-energy state. This excited state is unstable, however, and the
atoms will spontaneously return to their ground state by ridding
themselves of excess energy.As these atoms emit energy, light is produced. The light emitted
by a lamp full of atoms is disorganized and emitted in all directions
randomly. This type of light, common to all ordinary sources, from
fluorescent lamps to the Sun, is called “incoherent light.”
Laser light is different. The excited atoms in a laser emit their excess
energy in a unified, controlled manner. The atoms remain in the
excited state until there are a great many excited atoms. Then, they
are stimulated to emit energy, not independently, but in an organized
fashion, with all their light waves traveling in the same direction,
crests and troughs perfectly aligned. This type of light is called
“coherent light.”
Theory to Reality
In 1958, Charles Hard Townes of Columbia University, together
with Arthur L. Schawlow, explored the requirements of the laser in
a theoretical paper. In the Soviet Union, F. A. Butayeva and V. A.
Fabrikant had amplified light in 1957 using mercury; however, their
work was not published for two years and was not published in a
scientific journal. The work of the Soviet scientists, therefore, received virtually no attention in the Western world.
In 1960, Theodore Harold Maiman constructed the first laser in
the United States using a single crystal of synthetic pink ruby,
shaped into a cylindrical rod about 4 centimeters long and 0.5 centimeter
across. The ends, polished flat and made parallel to within
about a millionth of a centimeter, were coated with silver to make
them mirrors.
It is a property of stimulated emission that stimulated light
waves will be aligned exactly (crest to crest, trough to trough, and
with respect to direction) with the radiation that does the stimulating.
From the group of excited atoms, one atom returns to its ground state, emitting light. That light hits one of the other exited atoms and
stimulates it to fall to its ground state and emit light. The two light
waves are exactly in step. The light from these two atoms hits other
excited atoms, which respond in the same way, “amplifying” the total
sum of light.
If the first atom emits light in a direction parallel to the length of
the crystal cylinder, the mirrors at both ends bounce the light waves
back and forth, stimulating more light and steadily building up an
increasing intensity of light. The mirror at one end of the cylinder is
constructed to let through a fraction of the light, enabling the light to
emerge as a straight, intense, narrow beam.
Consequences
When the laser was introduced, it was an immediate sensation. In
the eighteen months following Maiman’s announcement that he had
succeeded in producing a working laser, about four hundred companies
and several government agencies embarked on work involving
lasers. Activity centered on improving lasers, as well as on exploring
their applications. At the same time, there was equal activity in publicizing
the near-miraculous promise of the device, in applications covering
the spectrum from “death” rays to sight-saving operations. A
popular film in the James Bond series, Goldfinger (1964), showed the
hero under threat of being sliced in half by a laser beam—an impossibility
at the time the film was made because of the low power-output
of the early lasers.
In the first decade after Maiman’s laser, there was some disappointment.
Successful use of lasers was limited to certain areas of
medicine, such as repairing detached retinas, and to scientific applications,
particularly in connection with standards: The speed of
light was measured with great accuracy, as was the distance to the
Moon. By 1990, partly because of advances in other fields, essentially
all the laser’s promise had been fulfilled, including the death
ray and James Bond’s slicer. Yet the laser continued to find its place
in technologies not envisioned at the time of the first laser. For example,
lasers are now used in computer printers, in compact disc
players, and even in arterial surgery.